Endocrine Abstracts

Background: A recent, large phase III study (n=162) showed that treatment with pasireotide rapidly decreased urinary free cortisol (UFC) levels and improved signs and symptoms in patients with Cushing’s disease. Here, we report the experience of a patient enrolled in this trial who received pasireotide for 36 months.Results: A 31-year-old male presented in June 2008 with persistent Cushing’s disease despite two previous pituitary surgica...

Introduction: Uterine leiomyoma (fibroid) is the most common solid tumor in reproductive-age women. Symptomatic leiomyomas affect millions of women through menorrhagia, abnormal uterine bleeding, and infertility. No effective treatment except surgery is available, partly because of the lack of effective animal models for screening new therapies. We established a new xenograft model by grafting primary cultured leiomyoma cells beneath the kidney capsule in super-immunodeficient...